Saudis to permit women to compete in Olympics

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Russia shifts from resource nationalism to globalism

ST PETERSBURG, Russia (Reuters) - President Vladimir Putin left global oil executives in little doubt as to who was the master of the world's largest energy reserves at Russia's answer to Davos.

The sky over St Petersburg was turning white at the end of the longest day of the year, and the financiers and leaders of global industry who had gathered as Putin's guests at this year's forum were retiring to lavish parties and rooftop bars.

But the chief executives of BP, ConocoPhillips, Shell and Chevron stood with a dozen colleagues in a dark, chairless foyer, shifting from foot to foot on Thursday as they waited three hours for an audience.

"No one was angry," said a European chief executive as he whiled away the wait by hashing out an equipment issue with a colleague. "There was a lot to talk about."

Putin has kept them waiting in the past, both for meetings and for deals, sometimes for years as they struggled to find a way in with a government that controls access to some of the world's largest untapped oil and gas reserves.

Putin, whose conviction that strategic resources should be in the hands of the state was laid out in his doctoral dissertation, has shown a willingness in the past few months to share prospective oil riches on a scale unprecedented since Russia's early post-Soviet years.

Three Arctic drilling deals, personally brokered by energy tsar Igor Sechin in the final days of Putin's four-year spell as prime minister, have opened up new possibilities after a decade in which Russia became a byword for resource nationalism.

The appeal of advanced Western technology needed to tap increasingly remote and challenging fields, and the attendant promise of a more modern, healthy economy has chipped away at the Kremlin's jealous guard of its natural resources.

It has also set off debate around long-standing tax policies that are designed to skim off oil industry revenues but have proven costly in terms of investment in new barrels.

"What strikes me is that they are very much aware of the fact that they have to open up to other countries," Maria van der Hoeven, head of the International Energy Agency, said in an interview at the annual St Petersburg International Economic Forum.

"It has to do with investments and it has to do with markets, with market diversification. They need to find the right methods to do that, the right regulatory framework to get the (international oil companies) coming into the country."

OUR RESERVES, THEIR TECHNOLOGY

When Putin finally joined the CEOs, he was at pains to be welcoming, first giving the floor to Peter Voser, the CEO of Shell, which has been identified in media reports as a potential new investor in Shtokman, a troubled Barents Sea gas project.

"Twenty-five percent of our oil is produced by companies with foreign partners. That should tell you how open our industry is to foreign capital. Not in all countries is there such broad participation by foreigners," he told the executives.

"I just got back from Mexico, where the G20 was held, and (the oil industry) is almost completely state controlled. In a market-oriented country like Norway, there is really just one big company, Statoil."

Russia has one thing in common with those countries: declines in its old production base, though Russia has managed to keep pumping at ever higher rates, hitting post-Soviet output peaks thanks to new fields launched at great cost.

So it was that Sechin, a former military translator in Africa, found himself defending his decision to share the state oil company's reserves with foreigners at the company's annual meeting last week when a skeptical shareholder asked him whether such deals were in Russia's national interest.

His answer echoed a refrain that has been repeated since the Rosneft first announced its intent to grant a foreign oil company access to a new hydrocarbon province that could harbor fields like the Soviet-era "supergiants" which sustained the country through its last decades: Our reserves, their capital, their risk and, most of all, their technology.

EXXON'S SECRET

If the executives' long wait for Putin belied a welcoming stance, the body language with Exxon executives - notable by their absence at the table with Putin - has been easier to read.

CEO Rex Tillerson, who flew to a Black Sea refinery town this month at Rosneft's invitation for a strategy presentation with Putin, was photographed seated next to the Russian president, inclining his head for a private word.

Exxon executives were guests of honor at Rosneft's AGM, where Sechin had frank praise for the American major and its focus on delivering value to shareholders.

An executive at a rival major said he believed that was not what won over Sechin and his Kremlin patron. "They have really gone in with technology," the executive said.

The challenge faced by the Russian industry, said a source from a company with a long history in offshore drilling, is to move from standardized bulk drilling and top-down design decisions at old West Siberian fields to unpredictable environments and prospective projects where new technology must be developed and honed along the way.

Therein is the deep attraction of technology transfer for the Russian government, which is caught in a Catch-22 situation: With 50 percent of its budget revenue from energy, it can neither afford to let the industry stagnate, nor can it remain so heavily dependent on a volatile commodity.

Most immediately for Rosneft, it must invest in future output growth while simultaneously retooling its Soviet-built refineries to meet rising demand for high-specification gasoline and prevent politically damaging petrol shortages.

The order of the queue of executives at Rosneft's stand at the St Petersburg convention centre was telling. Behind Eni and Statoil - there to finalize their drilling deals - was Andrei Kostin, CEO of state bank VTB, on hand to sign a new financing deal to help build a new refinery near Moscow.

It was a reminder that, despite Rosneft's outward-looking stance of recent months, its concerns - and the Kremlin's - gravitate back to the domestic marketplace.

And with little build on outside the energy industry besides a crippled Soviet industrial base and a small if growing band of entrepreneurs, the Kremlin must pin its hopes for a modern economy on its oldest resource of all.

"Russia's energy sector is, perhaps, now, and must remain over the near term, the driver for modernization of the country's economy," said Sechin.

(Editing by Douglas Busvine and Timothy Heritage)

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Genome-wide analysis shows previously undetected abnormalities in parents of affected children

ScienceDaily (June 24, 2012) ? The use of genome-wide array analysis^[1] in parents whose children are suspected of having a genetic disease shows that the parents frequently also have previously undetected genetic abnormalities, a researcher from The Netherlands told the annual conference of the European Society of Human Genetics June 24. Being aware of this is important to parents because it means that their risk of having another affected child is significantly increased.

Dr. Nicole de Leeuw, a clinical laboratory geneticist in the Department of Human Genetics of the Radboud University Nijmegen Medical Centre in Nijmegen, and colleagues performed genome-wide SNP^[2] array analysis in 6,500 patients and 1,874 parents. The patients had intellectual disability and/or congenital abnormalities, and the parents of those in whom an aberration was detected were tested in a similar way to determine whether they had the same aberration as their child. Mosaic aberrations, where both genetically normal and abnormal cells are present in an individual, were not only found in one in every 300 patients, but in one in every 270 parents as well. "These abnormalities occurred more frequently than we had expected," said Dr. de Leeuw. "Armed with this knowledge, we can try to understand not only why, but also how genetic disease arises in individuals, and this can help us to provide better genetic counselling."

Analysis of patients' genomes showed 6.5% de novo (spontaneously arising) genomic imbalances, 9.1% of rare, inherited imbalances, and 0.8% of X-linked abnormalities. Moreover, with the additional data from their SNP array test results, the researchers were able to subsequently find pathogenic mutations in recessive disease genes, uniparental disomies (where a single chromosome is doubled leading to two genetically identical ones), and mosaic aneuploidies (an extra or missing chromosome in some of the cells of the body) in about 30 patients.

"In at least seven families, these findings meant that what we had thought of as a spontaneously arising, non-inherited genetic abnormality in a child was in fact already present in some form in the parent," said Dr. de Leeuw. "Furthermore, when we tested in different cell lines -- for example, DNA from blood and that from a mouth swab -- we often found that results varied. This is because mosaic aberrations can occur in cells in some organs and not in others, and underlines the importance of not just relying on one type of cell line for this kind of genetic diagnosis."

In two cases these tissue-dependent differences changed over time, and the researchers believe that this was due to an attempt by the body to correct and rescue the situation. "Such rescue attempts are best known in cases of trisomy, where there are three chromosomes instead of two in a cell, or monosomy, where there is only one. In both these cases, the body may try to correct the situation by respectively deleting or adding (doubling) a chromosome. Such rescue mechanisms may be more common than we expected, and by using genome-wide SNP array analysis it will help us to reveal them. For some patients, it would be particularly interesting if we could test multiple samples of these patients over time," said Dr. de Leeuw.

The majority of genetic diseases are not treatable, but in some cases a special diet may reduce the severity of the symptoms ,for example, in phenylketonuria (PKU) or in coeliac disease, in others the same can be obtained by periodic examination of certain organs (for example in Down syndrome or Marfan syndrome). Sometimes hormone treatment will be of benefit to the patient, for example growth hormone treatment in Turner syndrome. For most patients with a genetic disorder, there is no cure, but knowing the genetic cause of their disease may help and improve the care for these patients through knowledge about other patients with the same disease. And if the family is at risk of a genetic disease, couples considering having children can be better informed as to their options, the researchers say.

"By using genome-wide array analysis to look for imbalances in the human genome, we will uncover more and more accurate findings in patients. This will not only increase our knowledge of genetic disorders and the human genome in general, but if we can also collect the clinical features of these patients in a structured and uniform way, the information will become increasingly valuable. Fortunately, this is becoming easier due to advances in tools and software applications, and many professionals in the academic and commercial world have agreed to collaborate in order to substantially increase the genotype/phenotype collection and make these anonymised data publicly available to medical professionals in order to improve patient care worldwide," Dr. de Leeuw concluded.

Notes:

[1] A DNA microarray (or gene chip) is a collection of microscopic DNA spots attached to a solid surface, used to measure the relative quantity of large numbers of genes simultaneously in multiple regions of a genome, thereby determining the DNA copy number.

[2] A SNP (pronounced 'snip'), or single nucleotide polymorphism, is a relatively common DNA sequence variation, a change in a single nucleotide -- A, T, C or G -- in the genome, without clinical consequences. Each person has about 3 million SNPs in his or her genome, a unique genetic signature. In a SNP microarray, the probes (small pieces of DNA) bind only to the complementary piece of DNA being analysed if it is an exact match, making it possible to determine the genotype (SNP composition) of a DNA sample in addition to the DNA copy number.

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The above story is reprinted from materials provided by European Society of Human Genetics (ESHG), via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Reform of Nike Air Max 2012 Is Not Equal to End of Its Popularity

Loved by so many people, Nike shoes have become the most popular sports shoes. Some brands may have got the best title in certain areas, but in comparison with them, Nike has achieved the highest honor, and this is unparalleled. Nike Company which is supposed to be the most famous one around the world has never stopped its advancing steps. from 1960s to 2010s, Nike products have been endowed with many improvements. types of Nike shoes and the technology inside these shoes have been improved a lot from the releasing of the first Nike Air shoes to the present famous Nike free shoes.
In the entire world, either the young or the old, all show great love to Nike shoes, and all expect to buy them. In addition, in order to gain more fame for its shoes; lots of spokespersons have been cooperated with Nike Company. Between Jordan times and Kobe's in NBA, more than ten players of the basketball area have been invited to endorse Nike shoes. Among these players, some has also got their unique Nike shoes. C Lo who is seen as a world widely famous football player has been invited to be the spokesman of Nike shoes in football area till 2010. Yet for Nike, this is not the end. Later it releases other kinds of shoes, such as Nike golf whose spokesperson is the most popular golf star Woods, Nike trainers, Nike running and so forth. In nearly all kinds of sports fields, you can find Nike shoes.
Nike's spirit pushes Nike Company forward. Nike's new series have adopted the high technology in Nike self-lacing shoes as the focus one. These Nike self-lacing shoes can treated as the improved version of Nike Air Max shoes which are the most famous ones among all Nike shoes in the whole world. In this way, the status of Nike Air Max seems to be faded by this reformation. Nowadays, the most famous basketball shoes have proved to be Nike Zoom Kobe ones. And these shoes are favored by many basketball fans. Nike Air Max will be likely to disappear from Nike Company if it doesn't make any improvements.
However, this rumor is soon eliminated because of appearance of Jordan. Jordan who inherits lots of talents from his father is used to wear Nike Air Jordan shoes in college. In this way, Nike Air Max also becomes choice for many students there. Then the basketball team in the college deices to cooperate with Nike instead of Adidas because of the excellent performance of little Jordan in basketball games. Then one inference can be got here, i.e., around the whole world, Nike Jordan shoes are still the most famous basketball ones, and this is also because of their advanced soles, making the wearers extremely comfortable. the policy of Nike Company has shown that this reform of Nike Air Max is only a kind of reuse of shoes but not the over of its basketball function.

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Europe tells UK to raise VAT on energy efficiency products

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Video: Shattered, Part 1

Dateline NBC

'Dateline NBC,' the signature broadcast for NBC News in primetime, premiered in 1992. Since then, it has been pioneering a new approach to primetime news programming. The multi-night franchise, supplemented by frequent specials, allows NBC to consistently and comprehensively present the highest-quality reporting, investigative features, breaking news coverage and newsmaker profiles.

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Ny health - HEALTH, BEAUTY & FITNESS

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